反应详情

In a mixture of 20 ml of chloroform and 10 ml of pyridine were dissolved 2.6 g of 4-aminobenzoic acid. To this mixture were added dropwise under cooling 20 ml of chloroform containing 3.2 g of 4-acetoxycinnamoyl chloride. The mixture was heated under reflux for 2 hours and the reaction mixture was concentrated under reduced pressure. The residue was poured into water and hydrochloric acid was then added to make the liquid weakly acidic. The precipitated crystals were collected by filtration and recrystallized from alcohol to yield 2.9 g of 4-(4'-acetoxycinnamoyl-amino)-benzoic acid. M.P. = 305°-307° C (with decomposition).

1. additionTo this mixture were added dropwise
2. temperatureThe mixture was heated
3. temperatureunder reflux for 2 hours
4. concentrationthe reaction mixture was concentrated under reduced pressure
5. additionThe residue was poured into water and hydrochloric acid
6. additionwas then added
7. filtrationThe precipitated crystals were collected by filtration
8. customrecrystallized from alcohol