Sulfuric Acid → HCID 178454904, compound

Participants

Reaction Steps

A solution of ethyl sec-butylphosphinite (25g., 0.17 mole) in tetrahydrofuran (50 ml.) was added dropwise to a cooled solution of iso-butyl magnesium bromide (0.4 mole) in tetrahydrofuran (150 ml.). The mixture was then heated under reflux for 18 hours. The mixture was then cooled, hydrolysed with 2N H2SO4, and extracted with methylene dichloride. The combined extracts were washed with NaHCO3 solution and then dried (MgSO4). The solvent was removed by distillation and the residue was distilled under reduced pressure to give isobutyl sec-butyl-phosphine oxide bp. 81°-3°/0.03 0.03 mm as a colourless liquid (yield 20g., 72%).

Provenance & Evidence