Acetic Anhydride → HCID 20373759, compound

Participants

Reaction Steps

To a solution of 2-(1-hydroxy-2-octynyl)-5-(tetrahydropyran-2-yloxy)-cyclopentaneheptanoic acid (11.5 g), described in Example 2, in dry pyridine (50 ml), acetic anhydride (35.6 ml) is added. The mixture is stirred overnight. The solvent is removed under reduced pressure. The residue is dissolved in ether and the solution is washed with ether, dried and concentrated to yield 2-(1-acetoxy-2-octynyl)-5-(tetrahydropyran-2-yloxy)-cyclopentaneheptanoic acid, (3; R1 = H, R2 = tetrahydropyran-2-yl and R3 = CH3CO), νmaxfilm 1700, 1735 cm-1.

Provenance & Evidence