Sulfuric Acid → HCID 20373854, compound

HRID 1834671Notes

Reaction equation

HRID 1834671 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([C:13](=[O:18])[C:14](=[CH2:17])[CH2:15][CH3:16])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([OH:8])=[O:7].S(=O)(=O)(O)O>>[O:18]=[C:13]1[C:11]2[C:10](=[CH:9][C:3]([O:4][CH2:5][C:6]([OH:8])=[O:7])=[C:2]([Cl:1])[CH:12]=2)[CH2:17][CH:14]1[CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 20373863HCID 20373863, compound

Product 1

HCID 20373854HCID 20373854, compound

Procedure

(1-Oxo-2-ethyl-6-chloro-5-indanyloxy)acetic acid is prepared by following substantially the same procedure as described in Example 1, Step A, using the following reagents: [2-chloro-4-(2-methylenebutyryl)phenoxy]acetic acid (41.32 g., 0.154 mole) and conc. sulfuric acid (165 ml.). The crude yield of the product is 38.8 g. (94%), m.p. 132°-138° C. Recrystallization from benzene gives (1-oxo-2-ethyl-6-chloro-5-indanyloxy)acetic as white prisms, m.p. 142°-144° C.

Workup

  1. customRecrystallization from benzene

Sources & evidence

ORD record
ord-3a92f78384464d1bb9006ea55e50c00a
Source dataset
uspto-grants-1978_01
Patent number
US04070539

Reaction notes

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