反应详情

温度

60 °C

[2,3-Dichloro-4-(2-methylene-4-methylvaleryl)phenoxy]-acetic acid (2.0 g., 0.006 mole) is added with stirring to concentrated sulfuric acid (10 ml.) and the mixture is heated at 60° C. for six hours. The reaction mixture is then cooled and poured into a mixture of ice and water (200 ml.) and the crude product which separates is ground in a mortar, filtered, washed with water and dried. After recrystallization from acetic acid (60 ml.) there is thus obtained 1.7 g. (85% yield) of (1-oxo-2-isobutyl-6,7-dichloro-5-indanyloxy)acetic acid, m.p. 191.5° C.

1. temperatureThe reaction mixture is then cooled
2. filtrationfiltered
3. washwashed with water
4. customdried
5. customAfter recrystallization from acetic acid (60 ml.) there