Water → HCID 20373894, compound

HRID 1834701Notes

Reaction equation

HRID 1834701 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][C:14]([CH3:19])([CH3:18])[C:15]([OH:17])=[O:16])=[C:8]([Cl:12])[C:9]=2[Cl:11])[CH2:4][CH:3]1[CH2:20][CH3:21].[Cl:22]Cl.O>C(O)(=O)C>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:13][C:14]([CH3:18])([CH3:19])[C:15]([OH:17])=[O:16])=[C:8]([Cl:12])[C:9]=2[Cl:11])[CH2:4][C:3]1([CH2:20][CH3:21])[Cl:22]

Participants

5

Reactant 3

HCID 962WaterHCID 24526ChlorineHCID 20373887HCID 20373887, compound

Product 1

HCID 20373894HCID 20373894, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

2-(1-Oxo-2-ethyl-6,7-dichloro-5-indanyloxy)-2-methylpropionic acid (4.7 g., 0.0014 mole) is dissolved in warm acetic acid (170 ml.) and treated with a solution of chlorine (1.06 g., 0.015 mole) in acetic acid (20 ml.) at 20° C. with stirring. The reaction mixture is kept at 20° C. for one hour and then at 80°0 C. for one hour. The reaction mixture is cooled and added to water (1 1.) with stirring. The white powder that separates is recrystallized from acetic acid-water (4:3) to obtain 3.0 g. of 2-(1-oxo-2-ethyl-2,67-trichloro-5-indanyloxy)-2-methylpropionic acid, m.p. 164.5°-165° C.

Workup

  1. waitfor one hour
  2. temperatureThe reaction mixture is cooled
  3. stirringwith stirring
  4. customThe white powder that separates is recrystallized from acetic acid-water (4:3)
  5. customto obtain 3.0 g

Sources & evidence

ORD record
ord-91fde82a2779465d9b74d3d450742c07
Source dataset
uspto-grants-1978_01
Patent number
US04070539

Reaction notes

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