Sodium Carbonate → HCID 3047599, compound

Participants

Reaction Steps

3-[2-(2-Dimethylaminoacetamido)-4-phenylthiophenyl]-2-methoxycarbonyliminothiazolidin-4-one hydrochloride (16.0 g; prepared as described in Example 1) was suspended in a mixture of water (150 ml) and chloroform (150 ml). Anhydrous sodium carbonate (1.75 g) was added, and the mixture was shaken vigorously. The chloroform layer was separated and the aqueous layer was extracted with a further quantity of chloroform (2 × 50 ml). The combined chloroform layers were dried over magnesium sulphate and evaporated. The residual solid obtained was crystallised from ethanol, with the aid of decolourising charcoal, to give 3-[2-(2-dimethylaminoacetamido)-4-phenylthiophenyl]-2-methoxycarbonyliminothiazolidin-4-one (13.1 g), m.p. 124°-126° C.

Provenance & Evidence