反应详情

To a stirred solution of 4.80 g of N-(2-ethylthioethyl)-glycine tert-butyl ester in 40 ml of chloroform was carefully added N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl chloride hydrochloride obtained above. The reaction mixture was allowed to stand at room temperature overnight. The reaction mixture was washed twice with 20 ml of saturated sodium chloride solution and evaporated to dryness. The residue was triturated with a small amount of water to give a powder. This was collected by filtration and reprecipitated with ethanol-diethyl ether to give 5.00 g of N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl-N-(2-ethylthioethyl)glycine tert-butyl ester.

1. customobtained above
2. washThe reaction mixture was washed twice with 20 ml of saturated sodium chloride solution
3. customevaporated to dryness
4. customThe residue was triturated with a small amount of water
5. customto give a powder
6. filtrationThis was collected by filtration
7. customreprecipitated with ethanol-diethyl ether