Potassium sodium tartarate → 1beta-Methyl-5-androstene-3beta,17beta-diol

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Reaction Steps

A tetrahydrofuran solution of 1β-methyl-5-androstene-3,17-dione so prepared is added under nitrogen to a solution of lithium tri-t-butoxyaluminum hydride in tetrahydrofuran. After stirring at room temperature for about 18 hours, an aqueous solution of potassium sodium tartrate is added with stirring to form a readily filterable white solid. The reaction mixture is filtered, the filtrate dried over magnesium sulfate, and the solvent removed from the filtrate. The residue which is crystallized from acetone-hexane yields 1β-methyl-5-androstene-3β,17β-diol.

Provenance & Evidence