HCID 22797450, compound → HCID 22797464, compound

HRID 1834937Notes

Reaction equation

HRID 1834937 reaction equation
[OH:1][CH2:2][C@@:3]12[C@@H:20]3[C@H:11]([C@H:12]4[C@@:16]([CH2:18][CH2:19]3)([CH3:17])[C:15](=[O:21])[CH2:14][CH2:13]4)[C@H:10]([CH3:22])[CH2:9][C:8]1=[CH:7][C:6](=[O:23])[CH2:5][C@H:4]2[CH3:24].[OH:25][CH2:26][C@@:27]12[C@@H:44]3[C@H:35]([C@H:36]4[C@@:40]([CH2:42][CH2:43]3)([CH3:41])[C:39](=[O:45])[CH2:38][CH2:37]4)[CH2:34][C@H:33]([CH3:46])[C:32]1=[CH:31][C:30](=[O:47])[CH2:29][C@H:28]2[CH3:48].OC[C@@]12[C@@H]3[C@H]([C@H]4[C@@](CC3)(C)C(=O)CC4)CCC1=CC(=O)C[C@H]2C>>[CH3:24][C@H:4]1[C@@:3]2([CH:2]=[O:1])[C:8]([CH2:9][C@@H:10]([CH3:22])[C@@H:11]3[C@@H:20]2[CH2:19][CH2:18][C@@:16]2([CH3:17])[C@H:12]3[CH2:13][CH2:14][C:15]2=[O:21])=[CH:7][C:6](=[O:23])[CH2:5]1.[CH3:48][C@H:28]1[C@@:27]2([CH:26]=[O:25])[C:32]([C@@H:33]([CH3:46])[CH2:34][C@@H:35]3[C@@H:44]2[CH2:43][CH2:42][C@@:40]2([CH3:41])[C@H:36]3[CH2:37][CH2:38][C:39]2=[O:45])=[CH:31][C:30](=[O:47])[CH2:29]1

Participants

5

Reactant 3

HCID 22797450HCID 22797450, compoundHCID 22797451HCID 22797451, compoundHCID 5427936919-Hydroxy-1beta-methyl-4-androsten-3,17-dione

Product 2

HCID 22797464HCID 22797464, compoundHCID 22797465HCID 22797465, compound

Procedure

Substituting 19-hydroxy-1β,7α-dimethyl-4-androstene- 3,17-dione and 19-hydroxy-1β,6α-dimethyl-4-androstene- 3,17-dione for the 19-hydroxy-1β-methyl-4-androstene-3,17 -dione above results in the preparation of 1β,7α-dimethyl- 4-androstene-3,17,19-trione and 1β,6α-dimethyl-4 -androstene-3,17,19-trione.

Sources & evidence

ORD record
ord-98099d3686d641ac8660ce273bd482e8
Source dataset
uspto-grants-1978_01
Patent number
US04071624

Reaction notes

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