2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 86734727, compound

Participants

Reaction Steps

17β,19-Dihydroxy-4-androsten-3-one dipropionate and dichlorodicyanobenzoquinone are refluxed in anhydrous dioxane for about 48 hours. The mixture is cooled and filtered. The filtrate is concentrated under vacuum, methylenechloride is added and the mixture filtered. The filtrate is washed well with water, dried over sodium sulfate and the solvent removed. Chromatography of the residue on silica gel and eluting with methylenechloride yields an eluate. Removal of the solvent results in a solid which is crystallized from an acetone-hexane solution to yield the desired 17β,19-dihydroxy-1,4-androstadien-3-one dipropionate.

Provenance & Evidence