HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-Ethoxy-1alpha-methyl-3,5-androstadien-17beta,19-diol dipropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 17beta,19-Dihydroxy-1alpha-methyl-4-androsten-3-one dipropionate | HCID 86734729 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-Ethoxy-1alpha-methyl-3,5-androstadien-17beta,19-diol dipropionate | HCID 70614567 | — |
Reaction Steps
A solution of 17β,19-dihydroxy-1α-methyl-4-androsten3-one dipropionate, triethylorthoformate, p-toluenesulfonic acid and ethanol in tetrahydrofuran is stirred at room temperature for about 2 hours. The reaction mixture is poured onto ice water containing a few drops of pyridine and stirred well. The solid which forms is filtered and crystallized from ethanol to yield pure 3-ethoxy-1α-methyl-3,5-androstadiene-17β,19-diol dipropionate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04071625 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-1d08688b2d604ab4930ee0346a1fa7f0 |
| Source note | uspto-grants-1978_01 |