反应详情

A solution of 19-trimethylsiloxy-5α-androstane-3β,17β-diol diacetate in ether is added to a lithium aluminum hydride suspension in ether. After refluxing for one hour, the excess hydride is destroyed with water. The ether solution is separated, dried over sodium sulfate and concentrated under vacuum. The residue which remains is crystallized from methanol to yield 19-trimethylsiloxy-5α-androstane-3β,17β-diol.

1. temperatureAfter refluxing for one hour
2. customthe excess hydride is destroyed with water
3. customThe ether solution is separated
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated under vacuum
6. customThe residue which remains is crystallized from methanol