HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1834970Generated: November 1, 2026
19-Trimethylsiloxy-5alpha-androstane-3beta,17beta-diol → 19-Trimethylsiloxy-5alpha-androstane-3,17-dione
https://huagongshe.com/reaction/1834970
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 19-Trimethylsiloxy-5alpha-androstane-3beta,17beta-diol | HCID 22801496 | — |
| Reactant | Jones' reagent | HCID 131709961 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 19-Trimethylsiloxy-5alpha-androstane-3,17-dione | HCID 22801527 | — |
Reaction Steps
19-Trimethylsiloxy-5α-androstane-3β,17β-diol is dissolved in acetone and chilled to 10° C. Jones reagent is added with stirring over a period of 5 minutes and the mixture left standing for an additional 20 minutes. The acetone layer is poured onto water with vigorous stirring. The solid which forms is collected by filtration, air dried and crystallized from an acetone-hexane solution to yield 19-trimethylsiloxy-5α-androstane-3,17-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04071625 |
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| Source dataset | uspto-grants-1978_01 |
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| ORD ID | ord-888799ce0873422a860e6f2f9ac77d9a |
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| Source note | uspto-grants-1978_01 |
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