HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1beta-Methyl-4-androstene-3,17-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 1beta,2beta-Methylene-4-androstene-3,17-dione | HCID 54262378 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1beta-Methyl-4-androstene-3,17-dione | HCID 54175784 | — |
Reaction Steps
A mixture of 1β,2β-methylene-4-androstene-3,17-dione, zinc powder, and acetic acid is refluxed for one hour. Benzene is added and the suspension filtered. The filtrate is taken to dryness under vacuum. The residue which remains is chromatographed on silica gel and eluted with methylenechloride. Recrystallization of the residue obtained from the eluate from an acetone-hexane solution yields 1β-methyl-4-androstene-3,17-dione.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04071625 |
| Source dataset | uspto-grants-1978_01 |
| ORD ID | ord-d364e8728dfd4f8da80507beca84897a |
| Source note | uspto-grants-1978_01 |