Ammonium Chloride → 1beta-Methyl-5-androstene-3,17-dione

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Reaction Steps

To a solution of potassium t-butoxide in dimethylsulfoxide under nitrogen at 25° C. is added 1β-methyl-4-androstene-3,17-dione in dimethylsulfoxide with stirring. After 15 minutes the mixture is poured onto a cold aqueous ammonium chloride solution. The solid which forms is rapidly filtered, washed well with water and redissolved in ether. The ether solution is washed with water and dried over sodium sulfate. The ether is removed at room temperature to yield 1β-methyl-5-androstene-3,17-dione.

Provenance & Evidence