HCID 86735434, compound → HCID 86735433, compound

HRID 1834991Notes

Reaction equation

HRID 1834991 reaction equation
[CH3:1][C@@H:2]1[CH:19]=[C:18]2[C@:13]([CH:21]=[O:22])([CH2:14][CH2:15][C:16](=[O:20])[CH2:17]2)[C@@H:12]2[C@@H:3]1[C@H:4]1[C@@:8]([CH2:10][CH2:11]2)([CH3:9])[C:7](=[O:23])[CH2:6][CH2:5]1>C(O)C.[Pd]>[CH3:1][C@@H:2]1[CH2:19][C@@H:18]2[C@:13]([CH:21]=[O:22])([CH2:14][CH2:15][C:16](=[O:20])[CH2:17]2)[C@@H:12]2[C@@H:3]1[C@H:4]1[C@@:8]([CH2:10][CH2:11]2)([CH3:9])[C:7](=[O:23])[CH2:6][CH2:5]1

Participants

4

Reactant 1

HCID 86735434HCID 86735434, compound

Product 1

HCID 86735433HCID 86735433, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 7α-methyl-5-androstene-3,17,19-trione in ethanol is hydrogenated with 5% palladium on charcoal. The catalyst is removed by filtration and the resulting solution evaporated to dryness. Crystallization of the residue from a pentane-ether solution results in the preparation of 7α-methyl-5α-androstane-3,17,19-trione.

Workup

  1. customThe catalyst is removed by filtration
  2. customthe resulting solution evaporated to dryness
  3. customCrystallization of the residue from a pentane-ether solution

Sources & evidence

ORD record
ord-4cbe527ac9cc4fb2acfb27adbd1262f4
Source dataset
uspto-grants-1978_01
Patent number
US04071625

Reaction notes

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