p-Toluenesulfonic acid → HCID 22801518, compound

Participants

Reaction Steps

17β,19-Dihydroxy-17α-methyl-5α-androstan-3-one in acetic acid is treated with ethanedithiol and p-toluenesulfonic acid. After standing for 4 hours at room temperature, the solution is poured onto water and the mixture extracted with methylenechloride. The methylenechloride extract is washed well with water, washed with a sodium hydroxide solution, washed again with water, dried over sodium sulfate and evaporated under reduced pressure to leave a residue of 17β,19-dihydroxy-17α-methyl-5α-androstan-3-one 3-ethylenethioketal which is crystallized once from a solution of acetone-hexane.

Provenance & Evidence