Chloroacetyl chloride → HCID 23502530, compound

Participants

Reaction Steps

4-Chloro-3-[7-fluoro-5-amino-2H-1,4-benzoxazine-3(4H)-on-6-yl]-1-methyl-5-trifluoromethyl-1H-pyrazole (400 mg, 1.10 mmol) was dissolved in anhydrous dioxane and chloroacetyl chloride (139.5 mg, 1.20 mmol) was added. Solution was heated to reflux for 2 hr and solvent removed in vacuo. The residue was washed with ether to afford the title compound (410 mg, 0.93 mmol).

Provenance & Evidence