Sodium hydride → HCID 131724510, compound

Participants

Reaction Steps

4-Chloro-3-[7-fluoro-5-(2-chloropropionylamino)-2H-1,4-benzoxazine-3(4H)-on-6yl]-1-methyl-5-difluoromethoxy-1H-pyrazole (300 mg, 0.66 mmol) was dissolved in anhydrous dimethylformamide (10 ml) and solution stirred under ice-cooling. Sodium hydride (20 mg, 95%, 0.79 mmol) was added slowly in portions and solution stirred at room temperature for 2 hr. Solution was then added to ice-water and product extracted with ethyl acetate. Evaporation of the solvent afforded a residue which was purified by flash chromatography on silica gel in hexane-ethyl acetate (1:1) to furnish the title compound (209.2 mg, 0.50 mmol).

Provenance & Evidence