Water → HCID 12993822, compound

Participants

Reaction Steps

3-[5-(2-Chloroacetylamino)-7-fluoro-2H-1,4-benzoxazine-3(4H)-on-6-yl]-1-methyl-6-trifluoromethyl-2,4-(1H,3H)-pyrimidinedione (271 mg, 0.60 mmol was dissolved in anhydrous acetonitrile (10 ml) and potassium iodide (14 mg, 0.08 mmol) and N,N-diisopropylethylamine (100.8 mg, 0.78 mmol) were added. Solution was refluxed for 2 hr. added to water and extracted with ethyl acetate. Product was purified by flash chromatography on silica gel with hexane-ethyl acetate (1:1) as eluent (218.6 mg, 0.53 mmol).

Provenance & Evidence