2-Bromo-2-methylpropionyl bromide → HCID 23502532, compound

Participants

Reaction Steps

5-Amino-7-fluoro-6-[4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2H-1,4-benzoxazine-3(4H)-one (1.0 g, 2.64 mmol) was dissolved in anhydrous dioxane (40 ml) and 2-bromoisobutyryl bromide (0.67 g, 2.91 mmol) was added. Solution was refluxed for 2 hr and solvent was then evaporated. The residue was triturated with ether to afford the title compound (1.02 g, 1.99 mmol).

Provenance & Evidence