Water → HCID 91406855, compound

Participants

Reaction Steps

5-(2-Bromoisobutyrylamino)-6-[4-chloro-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-7-fluoro-2H-1,4-benzoxazine-3(4H)-one (1.15 g, 2.24 mmol) was dissolved in anhydrous acetonitrile (50 ml) and potassium iodide (0.45 g, 2.70 mmol) and potassium carbonate (0.37 g, 2.70 mmol) were added. Solution was refluxed for 2 hr and water was added. Product was extracted with ethyl acetate and solvent evaporated. Column chromatography on silica gel using hexane-ethyl acetate (7:3) as eluent afforded the title compound (84.0 mg, 0.19 mmol).

Provenance & Evidence