Stearic Acid → Stearamidopropyl Dimethylamine

Participants

Reaction Conditions

Reaction Steps

(a-5) was synthesized by a dehydrating esterification reaction between stearic acid and N,N-dimethyl-1,3-propanediamine. Specifically, a four-neck flask equipped with a stirrer, a temperature gage and a dewatering pipe was charged with 120 g of N,N-dimethyl-1,3-propanediamine, 284 of stearic acid and 0.12 g of sodium borohydride and the mixture was raised to 180° C. The mixture was heated under stirring at this temperature for about 5 hours while distilling generated water and a part of N,N-dimethyl-1,3-propanediamine to be distilled together with water. The reaction mixture was then cooled to 120° C. and unreacted amine was distilled under reduced pressure (10 torr) to obtain 368 g of the target N-stearoylaminopropyl-N,N-dimethylamine (a-5).

Provenance & Evidence