2-(Dimethylamino)ethanol → HCID 14150950, compound

Participants

Reaction Conditions

Reaction Steps

(a″-1) was synthesized by a dehydrating esterification reaction between oleic acid and N-hydroxyethyl-N,N-dimethylamine. Specifically, a four-neck flask equipped with a stirrer, a temperature gage and a dewatering pipe was charged with 132 g of N-hydroxyethyl-N,N-dimethylamine and 400 g of oleic acid and the mixture was raised to 150° C. The mixture was heated under stirring at this temperature for 4 hours while distilling generated water. The resulting mixture was raised to 180° C. and continuously heated with stirring for 10 hours while 66 g of 2-dimethylaminoethanol was added dropwise. After that, the reaction mixture was cooled to 120° C., unreacted amine was distilled under reduced pressure and the reaction mixture was subjected to distillation to obtain 350 g of the target N-oleoyloxyethyl-N,N-dimethylamine (a″-1).

Provenance & Evidence