HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 8-amino-3,4-dimethyl-7-nitro-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-(3-Amino-2-cyano-4-nitrophenyl)-2-methyl-3-oxobutyric acid ethyl ester | HCID 11266714 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-amino-3,4-dimethyl-7-nitro-2H-isoquinolin-1-one | HCID 23502937 | 72% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
The ester from above (1.39 g, 4.56 mmol) was added to a mixture of acetic acid (20 mL), H2SO4 (3 mL) and water (2 mL), and the solution heated at 100° C. for 3 h. The cooled solution was diluted with water (30 mL), the precipitate was collected, washed with water and MeOH and dried to give 8-amino-3,4-dimethyl-7-nitro-2H-isoquinolin-1-one (0.76 g, 72%). mp >300° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06770639B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-1be837e95ca14a45b6100cc25b12fdec |
| Source note | uspto-grants-2004_08 |