Hydrochloric Acid → HCID 9953741, compound

Participants

Reaction Steps

To a stirred solution of the product of Example 9 (25 mg, 0.05 mmol), in THF (2 mL), under nitrogen, was added a solution of lithium aluminum hydride (1M in THF, 0.25 mL, 0.25 mmol). The mixture was stirred for 30min at room temperature. Ethyl acetate was added, followed by water, and then acidified with 1N HCl. The whole mixture was applied to a Varian SCX cartridge, and washed in turn with 1N HCl, water, acetone, MeOH, and MeOH/CH2Cl2 (1:1). The product was then eluted with MeOH/CH2Cl2/NH4OH (49:49:2). Evaporation of the eluent gave the title compound (15 mg, 72%). Mp >300° C.; MS(ES) 417, 419 (MH+).

Provenance & Evidence