HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl bromide → 2-(3-Bromopropyl)-1,3-difluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl bromide | HCID 68176 | — |
| Reactant | 3-(2,6-Difluorophenyl)propan-1-ol | HCID 23502764 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(3-Bromopropyl)-1,3-difluorobenzene | HCID 23502728 | — |
Reaction Steps
6.86 g (39.8 mmol) of 3-(2,6-difluorophenyl)propan-1-ol (Example 1.2.4) is dissolved in 50 ml toluene and 19.1 g (92.0 mmol) of thionyl bromide is added. The mixture is refluxed for 3 hours, the solvent is eliminated and excess thionyl bromide is eliminated. Then the residue is purified by flash chromatography (cyclohexane). Yield: 6.98 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06770636B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-87a782ebe2b240c1aca787c9900d4e54 |
| Source note | uspto-grants-2004_08 |