Acetic Acid → HCID 23502756, compound

Participants

Reaction Steps

150 mg (0.39 mmol) of [3-(2,6-difluorophenyl)propyl]-[1-(2,6-dimethylphenyl)-2-piperidin-1-ylethyl]amine (corresponds to Example 35) is placed in 3 ml of THF. Then 0.07 ml of DIPEA and 0.02 ml (0.39 mmol) of acetic acid are added; and finally 124.6 mg (0.39 mmol) of TBTU are added. The mixture is then stirred for 6 hours at room temperature, the solvent is eliminated, ethyl acetate and saturated NaHCO3 solution are added, and the resulting mixture is stirred for 15 minutes. The phases are separated and the organic phase is washed twice more with NaHCO3 solution and twice with saturated NaCl solution. The organic phase is dried and evaporated down and the residue is purified by flash chromatography (cyclohexane/ethyl acetate 7:3). MS: m/z 429 [(M+H)+].

Provenance & Evidence