HCID 9907010, compound → HCID 9825109, compound

HRID 1835142Notes

Reaction equation

HRID 1835142 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[C:6]2[CH:9]=[C:10]([CH2:12][C:13]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH:16]=[CH:15][CH:14]=3)[S:11][C:5]=2[C:4]([CH2:23][CH:24]([CH3:26])[CH3:25])=[N:3]1.C1(C)C=CC(S(=O)([S:35][CH2:36][CH2:37][CH2:38][O:39][Si](C(C)(C)C)(C)C)=O)=CC=1>>[OH:39][CH2:38][CH2:37][CH2:36][S:35][C:9]1[C:6]2[C:7](=[O:8])[N:2]([CH3:1])[N:3]=[C:4]([CH2:23][CH:24]([CH3:26])[CH3:25])[C:5]=2[S:11][C:10]=1[CH2:12][C:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 9907010HCID 9907010, compoundHCID 23503276HCID 23503276, compound

Product 1

HCID 9825109HCID 9825109, compound

Procedure

Prepared from 5-methyl-7-(2-methylpropyl)-2-(1-naphthalenylmethyl)thieno[2,3-d]-pyridazin-4(5H)-one (385 mg) prepared as described in Example 7 above and S-{3-[(1,1-dimethylethyl)dimethylsilyl]oxypropyl} paratoluenethiosulfonate (600 mg) (J. Med. Chem., 1995, 38, 2557) following the method of Example 3. Yield 370 mg.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-13ccaa35e7f74c2f8f534d8eb3a22b8f
Source dataset
uspto-grants-2004_08
Patent number
US06770646B2

Reaction notes

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