HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 23503295 | HCID 23503295 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Hydrochloric Acid | HCID 313 | 85% |
| Product | Diethyl 6-acetyl-5,6-dihydropyrido[3,4-b]pyrazine-7,7(8H)-dicarboxylate | HCID 9927112 | 84.4% |
Reaction Steps
To a solution of 1b (1.1 g, 2.36 mmol) in 40 mL THF was added NaH (170 mg, 4.25 mmol, 60% oil dispersion) under N2 and the solution was stirred for 30 min. The reaction was carefully quenched with water and extracted from sat NaHCO33× with EtOAc. The organic layers were dried with MgSO4, filtered, concentrated, and chromatographed on SiO2 using 75% EtOAc in hexane to give 640 mg of 1c as an HCl salt (85% yield). MS found: (M+H)+=322.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06770647B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-450575ba94314880b5a8b5099c0e8354 |
| Source note | uspto-grants-2004_08 |