Sodium Bicarbonate → HCID 10232267, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.12 g (0.18 mmol) N-(3,5-bis-trifluoromethyl-benzyl)-6-(4-bromoacetyl-piperazin-1-yl)-N-methyl-4-o-tolyl-nicotinamide, 1.2 ml 1-methyl-2-pyrrolidone and 0.2 ml half-saturated aqueous sodium bicarbonate solution was stirred at 100° C. over night. After cooling to room temperature and dilution with water the mixture was extracted with five portions of tert-butyl methyl ether. The combined organic extracts were dried with sodium sulfate, concentrated and dried in vacuo (0.5 mbar) at 70°. Flash column chromatography afforded 71 mg (64%) of the title compound as a white solid.

Provenance & Evidence