Ethyl Acetate → HCID 10166229, compound

Participants

Reaction Steps

To a solution of 30 mg (0.05 mmol) acetic acid (5-{[2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl]-methyl-amino}-4-o-tolyl-pyridin-2-ylcarbamoyl)-methyl ester in 2 ml tetrahydrofuran were added 2 ml 1 N sodium hydroxide solution at room temperature. After stirring for 15 min, ethyl acetate was added, the aqueous phase was separated and the organic layer was dried (sodium sulfate). After evaporation the residue was purified by flash-chromatography to give 15 mg (54%) of the title compound as white solid.

Provenance & Evidence