Chlorotrimethylsilane → HCID 10231820, compound

Participants

Reaction Steps

To a solution of 100 mg (0.20 mmol) N-(6-amino-4-o-tolyl-pyridin-3-yl)-2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-isobutyramide in 3 ml pyridine were added 54 mg (0.50 mmol) trimethylchlorosilane at room temperature. After stirring for 15 min, this mixture was added slowly under stirring to 155 mg (1.0 mmol) succinyl chloride and stirring was continued overnight. The solvent was removed in vacuo and the residue was purified by flash-chromatography to give 29 mg (25%) of the title compound as white solid.

Provenance & Evidence