N-(3,5-Bis-trifluoromethyl-benzyl)-6-iodo-N-methyl-4-o-tolyl-nicotinamide → HCID 23502878, compound

HRID 1835341Notes

Reaction equation

HRID 1835341 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[CH2:6][N:7]([CH3:24])[C:8](=[O:23])[C:9]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2C)=[CH:13][C:12]([I:22])=[N:11][CH:10]=1.[F:34]C(F)(F)C1C=C(C=C(C(F)(F)F)C=1)CN(C)C(=O)C1C(C2C=CC(F)=CC=2)=CC(Cl)=NC=1>>[F:29][C:28]([F:30])([F:31])[C:26]1[CH:25]=[C:5]([CH:4]=[C:3]([C:2]([F:32])([F:1])[F:33])[CH:27]=1)[CH2:6][N:7]([CH3:24])[C:8](=[O:23])[C:9]1[C:14]([C:15]2[CH:16]=[CH:17][C:18]([F:34])=[CH:19][CH:20]=2)=[CH:13][C:12]([I:22])=[N:11][CH:10]=1

Participants

3

Reactant 2

HCID 10231844N-(3,5-Bis-trifluoromethyl-benzyl)-6-iodo-N-methyl-4-o-tolyl-nicotinamideHCID 23502775HCID 23502775, compound

Product 1

HCID 23502878HCID 23502878, compound

Procedure

The title compound is prepared according to the procedure described above for the preparation of N-(3,5-bis-trifluoromethyl-benzyl)-6-iodo-N-methyl-4-o-tolyl-nicotinamide (Example 4) using N-(3,5-bis-trifluoromethyl-benzyl)-6-chloro-4-(4-fluoro-phenyl)-N-methyl-nicotinamide (Example 36) instead of N-(3,5-bis-trifluoromethyl-benzyl)-6-chloro-N-methyl-4-o-tolyl-nicotinamide.

Sources & evidence

ORD record
ord-4eedc300e7fc4aa3b2e9bc449b5f3aa2
Source dataset
uspto-grants-2004_08
Patent number
US06770637B2

Reaction notes

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