Ethylenediamine → HCID 86584826, compound

Participants

Reaction Steps

A mixture of 100 mg (0.198 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(6-phenylethynyl-4-o-tolyl-pyridin-3-yl)-isobutyramide (Example 72), 10 mg (0.17 mmol) ethylenediamine and 1 mg 10% palladium on carbon in 2 ml methanol was stirred at room temperature under an atmosphere of hydrogen gas for 8 h. The reaction mixture was filtered and concentrated. Column chromatography afforded 28 mg (24%) of the title compound as an orange viscous oil.

Provenance & Evidence