m-Chloroperbenzoic acid → HCID 10168247, compound

Participants

Reaction Steps

To a solution of 130 mg (0.210 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(3-methoxy-phenylsulfanyl)-4-o-tolyl-pyridin-3-yl]-N-methyl-isobutyramide (Example 103) in 1 ml dichloromethane a solution of 52 mg (0.21 mmol) 3-chloroperbenzoic acid in 1.5 ml dichloromethane was added at 0° C. After completed addition the reaction mixture was allowed to warm to room temperature and stirred over night. The reaction mixture was diluted with dichloromethane and washed with saturated aqueous sodium carbonate solution. The aqueous layer was extracted with three portions of dichloromethane. The combined organic layers were dried with sodium sulfate and concentrated. Column chromatography afforded 9 mg (7%) of the title compound as a colorless viscous oil.

Provenance & Evidence