Benzyl Bromide → HCID 23502804, compound

Participants

Reaction Steps

A mixture of 50 mg (0.11 mmol) N-(3,5-bis-trifluoromethyl-benzyl)-6-hydroxy-N-methyl-4-o-tolyl-nicotinamide (Example 111), 0.014 ml (0.12 mmol) benzyl bromide and 59 mg (0.21 mmol) silver carbonate in 2 ml dichloromethane was heated at reflux for 2 h. Cooling to room temperature was followed by dilution with dichloromethane and filtration. The filtrate was washed with water. The aqueous layer was extracted with three portions of dichloromethane. The combined organic layers were dried with sodium sulfate, concentrated and dried in high vacuo. Column chromatography afforded 24 mg (41%) of the title compound as a viscous light yellow oil.

Provenance & Evidence