2-Chloro-4-(trifluoromethyl)pyridine → (2-Methyl-4,5-(methylenedioxy)phenyl)(2-chloro-4-trifluoromethyl-3-pyridyl)methanol

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-4-(trifluoromethyl)pyridine	HCID 144958	—
Reactant	6-Methyl-2H-1,3-benzodioxole-5-carbaldehyde	HCID 3146242	—
Product	(2-Methyl-4,5-(methylenedioxy)phenyl)(2-chloro-4-trifluoromethyl-3-pyridyl)methanol	HCID 23503597	74.1%

Reaction Steps

Using 1.5 g (8.3 mmol) of 2-chloro-4-trifluoromethylpyridine and 1.4 g (8.2 mmol) of 2-methyl-4,5-(methylenedioxy)benzaldehyde, 2.1 g (yield 73%) of (2-methyl-4,5-(methylenedioxy)phenyl)(2-chloro-4-trifluoromethyl-3-pyridyl)methanol (m.p. 127-130° C.) was obtained by a process in accordance with step (a) of Synthesis Example 1.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06770662B2
Source dataset	uspto-grants-2004_08
ORD ID	ord-60e5129c7e494b898c589c0592d527a1
Source note	uspto-grants-2004_08