HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1835448Generated: October 31, 2026
Hydrochloric Acid → 3-(Thien-2-yl)benzoic acid
https://huagongshe.com/reaction/1835448
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-(2-thienyl)benzoate | HCID 4128465 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(Thien-2-yl)benzoic acid | HCID 736861 | 93.6% |
Reaction Steps
To a solution of 2-(3-methoxycarbonylphenyl)thiophene (1.29 g) in methanol (15 ml) and tetrahydrofuran (5 ml) was added an aqueous solution of sodium hydroxide (1N, 8.87 ml) followed by stirring for 2 hours at 60° C. To the mixture was added hydrochloric acid (1N, 10 ml). The resulting precipitate was collected by filtration and dried to give 2-(3-carboxyphenyl)thiophene (1.13 g, 93.4%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06770667B1 |
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| Source dataset | uspto-grants-2004_08 |
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| ORD ID | ord-2ae6f0e1d28e47dd86c0fe3a409b7781 |
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| Source note | uspto-grants-2004_08 |
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