HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Methyl-3-nitrophenyl)-pyrimidine → 2-Methyl-5-(pyrimidin-5-YL)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Methyl-3-nitrophenyl)-pyrimidine | HCID 23503663 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Methyl-5-(pyrimidin-5-YL)aniline | HCID 23503678 | 184.6% |
Reaction Steps
A suspension of 5-(4-methyl-3-nitrophenyl)-pyrimidine (258 mg) in tetrahydrofuran (5ml) and methanol (5 ml) was hydrogenated over palladium on carbon (10% w/w, 50% wet, 130 mg) under hydrogen atmosphere for 4 hours. The catalyst was filtered off and the filtrate was evaporated to give 5-(3-amino4-methylphenyl)pyrimidine(410 mg, 96.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06770667B1 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-2aaf6e3cc2b34a47b1400f7669979dda |
| Source note | uspto-grants-2004_08 |