反应详情

温度

200 °C

A mixture of 2′-(2,2-dimethyl-propionamido)-2,5′-difluoro-biphenyl-3-carboxylic acid methyl ester (92 mg) and pyridinium chloride (3.0 g) was stirred for 3 hours at 200° C., and then poured into ice-water. The suspension was stirred for 10 minutes. The precipitate was collected by filtration, washed with water and dried to give 6-fluoro-9H-carbazole-1-carboxylic acid (46 mg, 76.7%).

1. stirringThe suspension was stirred for 10 minutes
2. filtrationThe precipitate was collected by filtration
3. washwashed with water
4. customdried