Pyridine → 6-Chloro-imidazo[2,1-b]thiazole-5-sulfonic Acid [3-chloro-4-(naphthalen-2-ylsulfanyl)-phenyl]-amide

Participants

Role	Name	HCID	Charge
Reactant	Pyridine	HCID 1049	—
Reactant	6-Chloroimidazo(2,1-b)(1,3)thiazole-5-sulfonyl chloride	HCID 2799717	—
Reactant	3-Chloro-4-(napthalen-2-ylsulfanyl)-phenylamine	HCID 9861938	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	6-Chloro-imidazo[2,1-b]thiazole-5-sulfonic Acid [3-chloro-4-(naphthalen-2-ylsulfanyl)-phenyl]-amide	HCID 67255324	65%

Reaction Steps

The title compound was prepared using the method of example 94, starting with 3-chloro-4-(naphthalen-2-ylsulfanyl)-phenylamine (92) (150 mg, 0.53 mmol), pyridine (Aldrich, 0.21 mL, 2.63 mmol) and 6-chloro-imidazo[2,1-b]thiazole-5-sulfonyl chloride (Maybridge, 149 mg, 0.58 mmol) in THF. 172 mg (65%) of 98 was obtained as a pale yellow solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06770648B2
Source dataset	uspto-grants-2004_08
ORD ID	ord-763723fcc9944c52b41880108cdc21d9
Source note	uspto-grants-2004_08