Sodium Hydroxide → Ketoprofen

Participants

Reaction Steps

The solution of (5) (2.4 g, 0.009 mol) in methyl alcohol (25 ml) was added with 1N NaOH (13.5 ml) and the mixture was left under stirring for 8 hours at room temperature. After evaporating the solvent, the residue was diluted with water and 5% monobasic sodium phosphate was added drop by drop to the mixture to adjust pH to 5. The aqueous layer was then extracted with methyl acetate (2×100 ml). The collected organic extracts were dried over Na2SO4 and evaporated under vacuum, then crystallized from a benzene/petroleum ether 6:20 mixture to obtain 2.05 g of (6) (0.0081 mol; yield 90%) as a white solid (melting point 92-92° C.) following crystallization.

Provenance & Evidence