Ammonia → HCID 86759499, compound

HRID 1835640Notes

Reaction equation

[CH3:1][C:2]([C:5]#[C:6]/[CH:7]=[CH:8]/[CH2:9][N:10]([CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=12)[CH3:11])([CH3:4])[CH3:3].Cl.N.[C:25]([OH:30])(=[O:29])[CH:26]([CH3:28])[OH:27]>>[CH3:4][C:2]([C:5]#[C:6]/[CH:7]=[CH:8]/[CH2:9][N:10]([CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=12)[CH3:11])([CH3:1])[CH3:3].[C:25]([O-:30])(=[O:29])[CH:26]([CH3:28])[OH:27]

Participants

Reactant 3

HCID 222Ammonia

HCID 612Lactic Acid

HCID 5282481Terbinafine Hydrochloride

Product 1

HCID 86759499HCID 86759499, compoundYield 91.1%

Procedure

The reaction was conducted in the same manner as Example 1 with the difference that 17.5 g terbinafine-hydrochloride obtained in Step B were converted into the base by adding aqueous ammonia. The obtained product was reacted with 5 g lactic acid. 18.5 g terbinafine-lactate were obtained.

Sources & evidence

ORD record: ord-9ffc8d2e17f44570b1bdfa8addd73814
Source dataset: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06770786B1

Reaction notes

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