HCID 9894791, compound → HCID 11627998, compound

HRID 1835742Notes

Reaction equation

HRID 1835742 reaction equation
[C:1](NCCCCCCN1C2N=CN(C)C=2C(=O)N(CCCC[C@H](O)C)C1=O)(=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]1[C@@H:14]2[C@@H:9]([NH:10][C:11]([NH:13]2)=[O:12])[CH2:8][S:7]1.[C:42]([O:45][C@H:46]([CH3:66])[CH2:47][CH2:48][CH2:49][CH2:50][N:51]1[C:60](=[O:61])[C:59]2[N:58]([CH3:62])[CH:57]=[N:56][C:55]=2[N:54]([CH2:63][CH2:64][NH2:65])[C:52]1=[O:53])(=[O:44])[CH3:43]>>[C:1]([NH:65][CH2:64][CH2:63][N:54]1[C:55]2[N:56]=[CH:57][N:58]([CH3:62])[C:59]=2[C:60](=[O:61])[N:51]([CH2:50][CH2:49][CH2:48][CH2:47][C@H:46]([OH:45])[CH3:66])[C:52]1=[O:53])(=[O:15])[CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]1[C@@H:14]2[C@@H:9]([NH:10][C:11]([NH:13]2)=[O:12])[CH2:8][S:7]1.[C:42]([O:45][C@H:46]([CH3:66])[CH2:47][CH2:48][CH2:49][CH2:50][N:51]1[C:60](=[O:61])[C:59]2[N:58]([CH3:62])[CH:57]=[N:56][C:55]=2[N:54]([CH2:63][CH2:64][NH2:65])[C:52]1=[O:53])(=[O:44])[CH3:43]

Participants

4

Reactant 2

HCID 9894791HCID 9894791, compoundHCID 54415809HCID 54415809, compound

Product 2

HCID 11627998HCID 11627998, compoundHCID 54415809HCID 54415809, compound

Procedure

(R)-3-(N-Biotinyl-2-aminoethyl)-1-(5-hydroxyhexyl)-7-methylxanthine (CT13410) was prepared according to the method described above for (R)-3-(N-biotinyl-6-aminohexyl)-1-(5-hydroxyhexyl)-7-methylxanthine (CT 12460) but using (R)-1-(5-acetoxyhexyl)-3-(2-aminoethyl)-7-methylxanthine in place of (R)-1-(5-acetoxyhexyl)-3-(6-aminohexyl)-7-methylxanthine. The (R)-1-(5-acetoxyhexyl)-3-(2-aminoethyl)-7-methylxanthine was prepared according to the following procedure.

Sources & evidence

ORD record
ord-1de13d59fd5a4036a7c208a57a368845
Source dataset
uspto-grants-2004_08
Patent number
US06774130B2

Reaction notes

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