4-Chloro-1-naphthol → 4-Chloro-2-[(2-chlorophenyl)-piperidin-1-yl-methyl]-naphthalen-1-ol

HRID 1835773Notes

Reaction equation

HRID 1835773 reaction equation
[Cl-].[Cl:2][C:3]1[CH:15]=[CH:14][CH:13]=[CH:12][C:4]=1[CH:5]=[N+:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[Cl:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:20]([OH:27])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:20]([OH:27])=[C:19]([CH:5]([C:4]2[CH:12]=[CH:13][CH:14]=[CH:15][C:3]=2[Cl:2])[N:6]2[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]2)[CH:18]=1

Participants

3

Reactant 2

HCID 117874-Chloro-1-naphtholHCID 179587471-(2-Chloro-benzylidene)-piperidinium chloride

Product 1

HCID 101781914-Chloro-2-[(2-chlorophenyl)-piperidin-1-yl-methyl]-naphthalen-1-ol

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 1-(2-chloro-benzylidene)-piperidinium chloride and 4-chloro-1-naphthol.

Sources & evidence

ORD record
ord-ea7ee50fc87e45d0ac1afde8aea1de2b
Source dataset
uspto-grants-2004_08
Patent number
US06774136B2

Reaction notes

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