7-Methoxy-2-naphthol → 7-Methoxy-1-[(2-methoxyphenyl)-piperidin-1-yl-methyl]-naphthalen-2-ol

HRID 1835789Notes

Reaction equation

HRID 1835789 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9]([OH:13])=[CH:10]2)=[CH:5][CH:4]=1.[Cl-].[CH3:15][O:16][C:17]1[CH:29]=[CH:28][CH:27]=[CH:26][C:18]=1[CH:19]=[N+:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9]([OH:13])=[C:10]2[CH:19]([C:18]2[CH:26]=[CH:27][CH:28]=[CH:29][C:17]=2[O:16][CH3:15])[N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 8531737-Methoxy-2-naphtholHCID 179122761-(2-Methoxy-benzylidene)-piperidinium chloride

Product 1

HCID 235008677-Methoxy-1-[(2-methoxyphenyl)-piperidin-1-yl-methyl]-naphthalen-2-ol

Procedure

The preparation was carried out in accordance with general synthesis instructions 4 from 7-methoxy-2-naphthol and 1-(2-methoxy-benzylidene)-piperidinium chloride, which had been prepared in accordance with example 32.

Workup

  1. customhad been prepared in accordance with example 32

Sources & evidence

ORD record
ord-eb504de21363439991d8edfa3d5ad227
Source dataset
uspto-grants-2004_08
Patent number
US06774136B2

Reaction notes

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