Hydrochloric Acid → HCID 178419483, compound

Participants

Reaction Steps

A solution of bromine (0.99 g, 6.19 mmol) in 10% NaOH was slowly added to a suspension of indazole (1 g, 8.50 mmol) in 2 N NaOH (25 mL). The reaction mixture became a thick white slurry. After stirring for 2 hours, a small amount of sodium bisulfite was added and the solution was neutralized with 1 N HCl. The white solid was filtered and washed with water. Recrystallization from water gave 0.76 g (45% yield) of 3-bromoindazole 4a:

Provenance & Evidence