1,1'-Carbonyldiimidazole → 2H-1,2,4-Benzothiadiazin-3(4H)-one, 2-cyclopropyl-, 1,1-dioxide

Participants

Reaction Steps

A solution of of 2-amino-N-cyclopropyl-benzenesulfonamide (6.9 g, 32.5 mmol) in CH2Cl2 (50 ml) was treated with CDI (6.5 g, 40 mmol) and stirred for 12 h at reflux. The solution was a washed with HCl (1N), dried over MgSO4 and concentrated to give 6.5 g (84%) of 2-cyclopropyl-1,1-dioxo-1,4-dihydro-2H-1λ6-benzo[1,2,4]thiadiazin-3-one as a brown solid.

Provenance & Evidence